catastrophe

The massive earthquake was a major catastrophe that left thousands of people homeless.

(Chinese) 那次大地震是一场重大的灾难，导致成千上万的人无家可归。

Losing all the company's financial data in the fire was an absolute catastrophe for the firm.

(Chinese) 在火灾中丢失公司所有的财务数据对该公司来说绝对是一场灾难。