despair

As the floodwaters continued to rise, a sense of despair began to spread among the trapped villagers.

(Chinese) 随着洪水继续上涨，绝望感开始在受困的村民中蔓延。

He was driven to despair by the series of personal and professional failures he had endured.

(Chinese) 接连遭受的个人和职业失败让他陷入了绝望。