detriment

He worked long hours every day to the detriment of his physical and mental health.

(Chinese) 他每天长时间工作，损害了他的身心健康。

The new law was passed to the detriment of small business owners who could not afford the fees.

(Chinese) 新法律的通过对那些负担不起费用的中小企业主造成了损害。